Pallidal stimulation relieves myoclonus-dystonia syndrome.
case_report · Level V
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- Record sourced from PubMed, PMID 15965208.
- Also identified by PMC identifier 1739713.
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Abstract
A patient with myoclonus-dystonia syndrome was treated by implanting electrodes in the internal segment of the globus pallidus (GPi) and applying deep brain stimulation. Surgery was done in two sessions. The most affected limb was treated first and the other limb one year later. Neuronal recordings showed that most pallidal neurones discharged in bursts at a relatively low firing rate (mean (SD), 46 (18) Hz) compared with cells in the GPi in patients with Parkinson's disease. Neurones modified the rate and mode of discharge with dystonic postures and rapid involuntary contractions of limb muscles. Neurological examination at 24 months after surgery showed a decline of 47.8% and 78.5% in the Burke-Fahn-Marsden and disability rating scales, respectively.
Medical subject headings
- Dystonic Disorders
- Electric Stimulation Therapy
- Globus Pallidus
- Myoclonus