Tourette's syndrome and deep brain stimulation.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 15965209.
- Also identified by PMC identifier 1739716.
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Abstract
In this prospective double blind randomised "N of 1" study, a patient with a severe form of Tourette's syndrome was treated with bilateral high frequency stimulation of the centromedian-parafascicular complex (Ce-Pf) of the thalamus, the internal part of the globus pallidus (GPi), or both. Stimulation of either target improved tic severity by 70%, markedly ameliorated coprolalia, and eliminated self injuries. Severe forms of Tourette's syndrome may benefit from stimulation of neuronal circuits within the basal ganglia, thus confirming the role of the dysfunction of limbic striato-pallido-thalamo-cortical systems in this disorder.
Medical subject headings
- Electric Stimulation Therapy
- Globus Pallidus
- Intralaminar Thalamic Nuclei
- Tourette Syndrome