Detection of autoimmune regulator gene mutations in children with type 2 autoimmune hepatitis and extrahepatic immune-mediated diseases.
case_report · Level V
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Abstract
Autoimmune regulator gene mutations were identified in 3 children with type 2 autoimmune hepatitis and extrahepatic immune diseases, including 1 child with immune hepatitis recurrence after liver transplantation. These findings suggest that autoimmune regulator gene variants might predispose children to systemic autoimmune disease, a recurrence of immune disease, or both.
Medical subject headings
- Autoantibodies
- Cytochrome P-450 Enzyme System
- Hepatitis, Autoimmune
- Mutation
- Polyendocrinopathies, Autoimmune
- Transcription Factors