Life, death, and ubiquitin: taming the mule.
review · Level V
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Abstract
Ubiquitin-mediated protein degradation is an efficient way for the cell to get rid of unwanted proteins. A key player in this process is the E3 ubiquitin ligase. In this issue of Cell, and describe a new E3 ligase, ARF-BP1/Mule, which targets two very different substrates, p53 and Mcl-1, with completely different cellular outcomes.
Medical subject headings
- Neoplasm Proteins
- Proto-Oncogene Proteins c-bcl-2
- Tumor Suppressor Protein p53
- Ubiquitin
- Ubiquitin-Protein Ligases