BLM helicase complements disrupted type II telomere lengthening in telomerase-negative sgs1 yeast.
basic_science · Level V
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Abstract
Recombination-mediated pathways for telomere lengthening may be utilized in the absence of telomerase activity. The RecQ-like helicases, BLM and Sgs1, are implicated in recombination-mediated telomere lengthening in human cells and budding yeast, respectively. Here, we show that BLM expression rescues disrupted telomere lengthening in telomerase-negative sgs1 yeast. BLM helicase activity is required for this complementation, indicating BLM and Sgs1 resolve the same telomeric structures. These data support a conserved function for BLM and Sgs1 in recombination-mediated telomere lengthening.
Medical subject headings
- Adenosine Triphosphatases
- DNA Helicases
- Saccharomyces cerevisiae
- Saccharomyces cerevisiae Proteins
- Telomerase
- Telomere