ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL.
other · Level V
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- Record sourced from PubMed, PMID 16006523.
- Also identified by PMC identifier 1177379.
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Abstract
In human cells, the ELL family of transcription factors includes at least three members, which are all capable of stimulating the overall rate of elongation by RNA polymerase II by suppressing transient pausing by the enzyme at many sites along DNA. In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity. Our findings provide insights into the structure and function of ELL family transcription factors, and they bring to light direct roles for the EAF proteins in regulation of RNA polymerase II transcription.
Medical subject headings
- DNA
- DNA-Binding Proteins
- Gene Expression Regulation
- Neoplasm Proteins
- Peptide Elongation Factors
- Transcription Factors