Subtherapeutic ocular penetration of caspofungin and associated treatment failure in Candida albicans endophthalmitis.
case_report · Level V
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Abstract
Candida endophthalmitis represents the most serious ocular complication of candidemia. The pharmacokinetics and pharmacodynamics of fluconazole, amphotericin B, and flucytosine are fairly well established in endophthalmitis therapy. There remains a paucity of clinical data regarding the utility of new antimycotic agents in the treatment of fungal chorioretinitis and endophthalmitis. We report a case of clinical failure of caspofungin in the management of Candida albicans endophthalmitis associated with poor vitreous penetration.
Medical subject headings
- Antifungal Agents
- Candidiasis
- Endophthalmitis
- Peptides, Cyclic