Hypocretin-1 (orexin A) deficiency in acute traumatic brain injury.
prospective_cohort · Level II
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Abstract
Hypocretin-1 is involved in the regulation of the sleep-wake cycle. The authors prospectively assessed CSF hypocretin-1 levels in 44 consecutive patients with acute traumatic brain injury (TBI). Compared with controls, hypocretin-1 levels were abnormally lower in 95% of patients with moderate to severe TBI and in 97% of patients with posttraumatic brain CT changes. Hypocretin-1 deficiency after TBI may reflect hypothalamic damage and be linked with the frequent development of posttraumatic sleep-wake disorders.
Medical subject headings
- Brain Injuries
- Hypothalamic Diseases
- Hypothalamus
- Intracellular Signaling Peptides and Proteins
- Neuropeptides
- Sleep Wake Disorders