Multiple disseminated large-cell acanthomas of the skin associated with human papillomavirus type 6.

Berger, Thomas; Stockfleth, Eggert; Meyer, Thomas; Kiesewetter, Franklin; Funk, Jens Oliver · J Am Acad Dermatol · 2005

case_report · Level V

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Abstract

Cutaneous acanthomas encompass many clinically distinct types. We describe a patient with multiple nodules on the skin of the upper limbs which were histologically diagnosed as large-cell acanthomas. Further analysis revealed, surprisingly, the presence of human papillomavirus (HPV) type 6 within these lesions. HPV type 6 should therefore be considered an important cofactor in the pathogenesis of large-cell acanthomas.

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