In vivo development of high-level fluoroquinolone resistance in Streptococcus pneumoniae in chronic obstructive pulmonary disease.
case_series · Level IV
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- Record sourced from PubMed, PMID 16028169.
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Abstract
Patients with chronic obstructive pulmonary disease are generally subjected to multiple regimens of antimicrobial treatment. The development of high-level levofloxacin resistance (i.e., a minimum inhibitory concentration >8 mu g/mL) in 8 patients whose previous pneumococcal isolates showed susceptibility is described. Molecular methods were used to characterize the strains and to study the sequential changes in fluoroquinolone targets.
Medical subject headings
- Anti-Bacterial Agents
- Drug Resistance, Bacterial
- Levofloxacin
- Ofloxacin
- Pneumococcal Infections
- Pulmonary Disease, Chronic Obstructive
- Streptococcus pneumoniae