What is the risk of sham surgery in Parkinson disease clinical trials? A review of published reports.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 16033990.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Placebo, or sham surgery, as a control condition in surgical clinical trials in Parkinson disease (PD) remains controversial. The authors reviewed the adverse effects reported in double blind, placebo surgery controlled trials for PD. Placebo surgeries were generally safe and well tolerated but the number of subjects receiving the procedure was small. Harm occurred more frequently in subjects randomized to the experimental intervention.
Medical subject headings
- Neurosurgical Procedures
- Parkinson Disease
- Placebos