Lethal cardiomyopathy in epidermolysis bullosa associated with amitriptyline.
case_report · Level V
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- Record sourced from PubMed, PMID 16040888.
- Also identified by PMC identifier 1720547.
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Abstract
There are previous reports of dilated cardiomyopathy (DCM) in recessive dystrophic epidermolysis bullosa (RDEB), a debilitating blistering skin disorder. The pathogenesis of DCM in RDEB remains uncertain, although dietary deficiency of selenium and carnitine have been implicated. A 6 year old girl with RDEB who died of DCM is reported; attention is drawn to the possible role of two potentially cardiotoxic drugs, amitriptyline and cisapride.
Medical subject headings
- Amitriptyline
- Antidepressive Agents, Tricyclic
- Cardiomyopathy, Dilated
- Epidermolysis Bullosa