Mechanical hyperalgesia in complex regional pain syndrome: a role for TNF-alpha?
cross_sectional · Level IV
Where this comes from
- Record sourced from PubMed, PMID 16043808.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Plasma concentrations of soluble tumor necrosis factor alpha (TNF-alpha) receptor type I (sTNF-RI) were assessed in two complex regional pain syndrome (CRPS) patient groups (n = 30 and n = 16) and healthy controls (n = 25). Patients with CRPS and mechanical hyperalgesia had higher levels of sTNF-RI (1,661.8 +/- 146.8 pg/mL) compared with those with CRPS with identical clinical appearance but without hyperalgesia (1,155.9 +/- 56.3 pg/mL) and controls (1,239.5 +/- 42.9 pg/mL). This study suggests involvement of TNF-alpha in mechanical hyperalgesia of CRPS.
Medical subject headings
- Complex Regional Pain Syndromes
- Hyperalgesia
- Receptors, Tumor Necrosis Factor, Type I
- Tumor Necrosis Factor-alpha