Chromosome 1p loss: a favorable prognostic factor in low-grade gliomas.
retrospective_cohort · Level III
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Abstract
Search for loss of heterozygosity on chromosomes 1p, 9p, 10q, and 19q, epidermal growth factor receptor (EGFR) gene amplification, and p53 expression was performed in a series of 131 low-grade gliomas. The profile of molecular changes, clinical findings, and histology were subsequently correlated with the course of the disease, mainly progression-free survival. When these parameters were considered as candidate variables in a multivariate analysis, only loss of heterozygosity on chromosome 1p was associated with increased progression-free survival (hazard ratio, 0.521), indicating a major favorable prognostic role of this genetic alteration in low-grade gliomas.
Medical subject headings
- Brain Neoplasms
- Chromosome Deletion
- Chromosomes, Human, Pair 1
- Glioma
- Loss of Heterozygosity