Birth of a prion: spontaneous generation revisited.
review · Level V
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- Record sourced from PubMed, PMID 16051142.
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Abstract
The proposal that the transmissible agent in prion diseases can be a conformationally altered host protein that multiplies by autocatalytic conversion has gained wide acceptance. Recent work shows that the agent, the prion, can be replicated in a cell-free system, that it can be generated de novo, and that the strain-specific properties of prions are encoded by conformational variations of the underlying protein.
Medical subject headings
- Prions