Sildenafil increases cerebrovascular reactivity: a transcranial Doppler study.
rct · Level II
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- Record sourced from PubMed, PMID 16051646.
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Abstract
The authors performed a double-blind, placebo-controlled study in 28 patients to evaluate the effects of sildenafil on cerebral hemodynamics. A significant improvement of cerebrovascular reactivity, without any modification of other variables, was recorded 1 hour after the administration of 50 mg sildenafil. Further investigations are needed to evaluate whether cerebrovascular reactivity improvement could contribute to triggering sildenafil-induced migraine.
Medical subject headings
- Cerebral Arteries
- Cerebrovascular Circulation
- Phosphodiesterase Inhibitors
- Piperazines