Getting fat: two new players in molecular adipogenesis.
editorial · Level V
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- Record sourced from PubMed, PMID 16054047.
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Abstract
A transcription factor cascade drives adipogenesis. Two new members of this cascade have been uncovered--Kruppel-like factor 5 (KLF5), which is induced by C/EBPbeta and delta and acts in concert with C/EBPalpha, beta, and delta to activate PPARgamma2 expression, and Krox20, which is upstream of C/EBPbeta expression and one of the earliest factors induced during adipogenesis.
Medical subject headings
- Adipocytes
- CCAAT-Enhancer-Binding Protein-alpha
- CCAAT-Enhancer-Binding Protein-beta
- CCAAT-Enhancer-Binding Proteins
- DNA-Binding Proteins
- Transcription Factors