All roads lead to FoxO.
editorial · Level V
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- Record sourced from PubMed, PMID 16054064.
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Abstract
Stress-activated kinases control metabolism by antagonizing the early steps of insulin signal transduction. Two papers now demonstrate that Jnk, the prototypical stress-activated kinase, controls life span in Drosophila and C. elegans by promoting phosphorylation of the forkhead protein FoxO (Oh et al., 2005; Wang et al., 2005). The findings provide yet another mechanism by which metabolic and stress responses are integrated via phosphorylation of FoxO proteins.
Medical subject headings
- Caenorhabditis elegans Proteins
- Drosophila Proteins
- Insulin
- Mitogen-Activated Protein Kinases
- Signal Transduction
- Transcription Factors