AMPK and p53 help cells through lean times.
review · Level V
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- Record sourced from PubMed, PMID 16054073.
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Abstract
Cells that encounter low nutrient conditions often respond by arresting cell division or becoming apoptotic. Recent work by Jones and colleagues (Jones et al.,2005) reveals how the AMP-activated kinase mediates this process by phosphorylating and activating the tumor suppressor p53.
Medical subject headings
- Cells
- Multienzyme Complexes
- Protein Serine-Threonine Kinases
- Tumor Suppressor Protein p53