Kisspeptins and GPR54--the new biology of the mammalian GnRH axis.
review · Level V
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Abstract
Recent genetic evidence in humans and from mouse knockouts has linked kisspeptin-driven GPR54 signaling to the regulation of GnRH release from the hypothalamus. These molecules appear to represent a previously unsuspected control point for GnRH secretion, with important implications for the biology and pathology of the sex steroid axis.
Medical subject headings
- Gonadotropin-Releasing Hormone
- Proteins
- Receptors, Neuropeptide