Social defeat: risk factor for schizophrenia?

Selten, Jean-Paul; Cantor-Graae, Elizabeth · Br J Psychiatry · 2005

editorial · Level V

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Abstract

The hypothesis that chronic and long-term experience of 'social defeat' may increase the risk for schizophrenia is proposed. This increased risk may result from sensitisation of the mesolimbic dopamine system and/or increased baseline activity of this system. Data supporting the social defeat hypothesis are presented.

Medical subject headings