Comparative genomic hybridization in extramammary Paget's disease.
basic_science · Level V
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Abstract
Extramammary Paget's disease (EMPD) is a distinct skin cancer of unknown histogenesis. Data from genome-wide surveys for chromosomal aberrations in EMPD are limited. To identify chromosomal aberrations that are present in EMPD. Fifteen cases of EMPD were analysed by comparative genomic hybridization (CGH). We used pooled DNA CGH, instead of studying a single sample. In addition, immunohistochemistry was performed for detection of androgen receptor (AR). The most recurrent change was amplification at chromosomes Xcent-q21 and 19, and loss at 10q24-qter. In addition, expression of AR, located in chromosome X, was found in six cases. Results suggest that AR may play a role in EMPD tumorigenesis.
Medical subject headings
- Chromosome Aberrations
- Paget Disease, Extramammary