Eight base changes are sufficient to convert a leucine-inserting tRNA into a serine-inserting tRNA.
other · Level V
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- Record sourced from PubMed, PMID 1608979.
- Also identified by PMC identifier 49356.
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Abstract
Each aminoacyl-tRNA synthetase must functionally distinguish its cognate tRNAs from all others. We have determined the minimum number of changes required to transform a leucine amber suppressor tRNA to serine identity. Eight changes are required. These are located in the acceptor stem and in the D stem.
Medical subject headings
- Escherichia coli
- RNA, Transfer, Leu
- RNA, Transfer, Ser