Fluid retention mediated by renal PPARgamma.
basic_science · Level V
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- Record sourced from PubMed, PMID 16098822.
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Abstract
Thiazolidinediones are activators of the nuclear receptor PPARgamma with proven efficacy on glucose homeostasis. However, treatment with these drugs often results in fluid retention and edema. Recent studies establish a role for PPARgamma in renal sodium reabsorption, providing a mechanism for the plasma volume expansion induced by these drugs.
Medical subject headings
- Edema
- Kidney
- PPAR gamma