Diabetic pancreatic beta cells ARNT all they should be.
basic_science · Level V
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- Record sourced from PubMed, PMID 16098823.
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Abstract
A complex network of interacting transcription factors plays a critical role in normal pancreatic beta cell function, with mutations in certain transcription factor genes known to cause diabetes. In a recent issue of Cell, Gunton et al.(2005) demonstrate a role for the transcription factor ARNT/HIF1beta (hydrocarbon nuclear receptor translocator/hypoxia-inducible factor 1 beta) in normal beta cell function. ARNT expression is reduced in diabetic human islets and beta cell-specific ARNT knockout mice show the impaired glucose tolerance and abnormal insulin secretion that are characteristic of type 2 diabetes.
Medical subject headings
- DNA-Binding Proteins
- Diabetes Mellitus, Type 2
- Islets of Langerhans
- Receptors, Aryl Hydrocarbon
- Transcription Factors