Cardiac 123I-MIBG scintigraphy in patients with drug induced parkinsonism.
case_control · Level III
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- Record sourced from PubMed, PMID 16103041.
- Also identified by PMC identifier 2077722.
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Abstract
Cardiac sympathetic dysfunction was investigated using 123I-metaiodobenzylguanidine (MIBG) myocardial scintigraphy in 20 patients with drug induced parkinsonism (DIP). The mean heart to mediastinum ratio was significantly greater in patients with DIP than in those with Parkinson's disease (mean (SD): 2.07 (0.39) v 1.28 (0.15), p<0.001). MIBG uptake was not different between the DIP patients and controls. Two DIP patients whose MIBG uptake was significantly reduced showed persistent parkinsonism and responded dramatically to levodopa.
Medical subject headings
- Antipsychotic Agents
- Calcium Channel Blockers
- Dopamine Antagonists
- Heart Diseases
- Parkinsonian Disorders
- Technetium Tc 99m Sestamibi
- Tomography, Emission-Computed, Single-Photon