The effect of topical steroids on cutaneous oxygen tension.
case_series · Level IV
Where this comes from
- Record sourced from PubMed, PMID 1610691.
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Abstract
The precise mode of action of topically applied steroids is unknown. We have applied clobetasol propionate 0.05% ointment (Dermovate; Glaxo Pharmaceuticals) under occlusion to the forearm skin of 10 healthy volunteers for 6 h and monitored transcutaneous oxygen tension at the site for 19 h after its removal. Compared to the ointment base, the steroid-treated area was significantly hypoxic up to 13 h after application. The profound hypoxia present at the site of application of clobetasol propionate 0.05% ointment may account for some of its anti-inflammatory effects, and its atrophogenicity.
Medical subject headings
- Blood Gas Monitoring, Transcutaneous
- Clobetasol
- Skin