rTMS of supplementary motor area modulates therapy-induced dyskinesias in Parkinson disease.
case_series · Level IV
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Abstract
The neural mechanisms and circuitry involved in levodopa-induced dyskinesia are unclear. Using repetitive transcranial magnetic stimulation (rTMS) over the supplementary motor area (SMA) in a group of patients with advanced Parkinson disease, the authors investigated whether modulation of SMA excitability may result in a modification of a dyskinetic state induced by continuous apomorphine infusion. rTMS at 1 Hz was observed to markedly reduce drug-induced dyskinesias, whereas 5-Hz rTMS induced a slight but not significant increase.
Medical subject headings
- Apomorphine
- Dyskinesia, Drug-Induced
- Motor Cortex
- Transcranial Magnetic Stimulation