Botulinum toxin injections do not improve freezing of gait in Parkinson disease.
rct · Level II
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Abstract
Freezing of gait (FOG) is common in patients with Parkinson disease (PD) and responds poorly to medical treatment. Botulinum toxin A (BTX-A) injections into calf muscles decreased FOG in previous open-label studies. The authors conducted a randomized double-blind placebo-controlled crossover study of BTX-A vs placebo in 12 subjects with PD and FOG. No significant improvement with BTX-A was found using subjective and objective measures.
Medical subject headings
- Botulinum Toxins, Type A
- Gait Disorders, Neurologic
- Muscle, Skeletal
- Parkinson Disease