Nocturnal sleep apnea/hypopnea is associated with lower memory performance in APOE epsilon4 carriers.
cross_sectional · Level IV
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Abstract
The authors investigated the relationship between obstructive sleep apnea/hypopnea (OSAH) and cognition in 36 older adults, 18 APOE epsilon4 carriers, and 18 non-carriers. Greater numbers of respiratory events negatively impacted memory function in epsilon4 carriers only. This is the first study to provide preliminary evidence for a negative interaction of APOE epsilon4 and OSAH on memory in older adults, which may have important implications for treating cognitive decline and delaying dementia onset.
Medical subject headings
- Apolipoproteins E
- Genetic Predisposition to Disease
- Heterozygote
- Memory Disorders
- Sleep Apnea Syndromes