A new map for navigating the yeast epigenome.
review · Level V
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Abstract
The posttranslational modification of histones by acetylation or methylation regulates chromatin structure and can determine how a DNA sequence is interpreted by, for example, the transcriptional machinery. In this issue of Cell, Pokholok and colleagues (2005) describe a new and reliable genome-wide microarray study of histone modifications and gene expression in yeast. Their epigenetic map can be used to guide further research on the epigenome.
Medical subject headings
- Epigenesis, Genetic
- Gene Expression Regulation, Fungal
- Genome, Fungal
- Histones
- Saccharomyces cerevisiae