Inositol polyphosphate multikinase is a nuclear PI3-kinase with transcriptional regulatory activity.
basic_science · Level V
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- Record sourced from PubMed, PMID 16123124.
- Also identified by PMC identifier 1200306.
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Abstract
Phosphatidylinositol 3,4,5-trisphosphate is a major intracellular messenger molecule thought to be formed almost exclusively by cytosolic, wortmannin-inhibited phosphoinositide 3-kinase family members. Inositol polyphosphate multikinase was identified as an enzyme that generates a series of water-soluble inositol phosphates. We now report the robust, physiologic, and evolutionarily conserved phosphoinositide 3-kinase activity of inositol polyphosphate multikinase, which is localized to nuclei and unaffected by wortmannin. In yeast, this inositol lipid kinase activity physiologically regulates transcription.
Medical subject headings
- Cell Nucleus
- Gene Expression Regulation
- Phosphatidylinositol 3-Kinases
- Phosphotransferases (Alcohol Group Acceptor)
- Transcription, Genetic