Bacterial meningitis in children: a French prospective study.

Bingen, Edouard; Levy, Corinne; de la Rocque, France; Boucherat, Michel; Varon, Emmanuelle; Alonso, Jean Michel; Dabernat, Henri; Reinert, Philippe et al. · Clin Infect Dis · 2005

prospective_cohort · Level II

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Abstract

From January 2001 through December 2003, a total of 1084 children with bacterial meningitis were enrolled in a prospective French nationwide survey. The most frequent pathogens found in children older than 28 days were Neisseria meningitis (55.3%) and Streptococcus pneumoniae (33.4%). S. pneumoniae was the most frequent pathogen found among infants aged 2-12 months (49.5%), whereas N. meningitidis was the most frequent pathogen among children >12 months old (69.7%). Approximately one-half of S. pneumoniae isolates had diminished susceptibility to penicillin. The case-fatality rates were 7.6% for children with N. meningitidis meningitis and 10.8% for children with S. pneumoniae infection.

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