"Bound" to work: the free hormone hypothesis revisited.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 16143095.
- No licence information is recorded for this record.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
Megalin is a member of the low-density lipoprotein receptor-related protein (LRP) family. The plasma membrane-anchored LRPs serve as receptors for a wide variety of extracellular ligands, promoting their entry into cells by endocytosis of the receptor-ligand complex. In this issue of Cell, Hammes et al. (2005) show that resistance (insensitivity) to sex steroid hormones is encountered in animals lacking megalin. These data provide important insights into an endocytic mechanism for the uptake of sex steroids by mammalian cells.
Medical subject headings
- Gonadal Steroid Hormones
- Low Density Lipoprotein Receptor-Related Protein-2