GLUT4 trafficking in a test tube.
basic_science · Level V
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- Record sourced from PubMed, PMID 16154097.
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Abstract
Insulin regulates glucose transport in muscle and fat cells by stimulating the translocation of GLUT4 from intracellular vesicles to the plasma membrane. In this issue of Cell Metabolism, Holman and colleagues reconstitute this process in vitro, providing a system that promises new breakthroughs in our understanding of this important metabolic process.
Medical subject headings
- Cell Membrane
- Insulin
- Membrane Fusion
- Monosaccharide Transport Proteins
- Muscle Proteins
- Transport Vesicles