Regional cortical thinning in preclinical Huntington disease and its relationship to cognition.
cross_sectional · Level IV
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Abstract
The authors studied presymptomatic individuals with the Huntington disease (HD) mutation to determine whether cortical thinning was present. They found thinning that was regionally selective, semi-independent of striatal volume loss, and correlated with cognitive performance. Early, extensive cortical involvement occurs during the preclinical stages of HD.
Medical subject headings
- Cerebral Cortex
- Cognition Disorders
- Huntington Disease