Lamotrigine associated with exacerbation or de novo myoclonus in idiopathic generalized epilepsies.
case_series · Level IV
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Abstract
Five patients with idiopathic generalized epilepsies (IGE) treated with lamotrigine (LTG) experienced exacerbation or de novo appearance of myoclonic jerks (MJ). In three patients, LTG exacerbated MJ in a dose-dependent manner with early aggravation during titration. MJ disappeared when LTG dose was decreased by 25 to 50%. In two patients, LTG exacerbated MJ in a delayed but more severe manner, with myoclonic status that only ceased after LTG withdrawal.
Medical subject headings
- Anticonvulsants
- Brain
- Dyskinesia, Drug-Induced
- Epilepsy
- Myoclonus
- Triazines