Controlled trial of methotrexate versus 10-deazaaminopterin in the treatment of rheumatoid arthritis.
rct · Level II
Where this comes from
- Record sourced from PubMed, PMID 1616322.
- Also identified by PMC identifier 1005689.
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Abstract
A 15 week double blind controlled trial of methotrexate and 10-deazaaminopterin for the treatment of rheumatoid arthritis (RA) was performed in 26 patients. Significant improvement in all measured clinical parameters was observed in the two patient groups. The drugs were well tolerated; only one patient (10-deazaaminopterin) withdrew from the study because of side effects. It is concluded that, in the context of this relatively short clinical trial, 10-deazaaminopterin is at least as beneficial as methotrexate in the treatment of RA.
Medical subject headings
- Aminopterin
- Arthritis, Rheumatoid
- Folic Acid Antagonists
- Methotrexate