Antiphospholipid antibodies in homozygous sickle cell disease.
case_control · Level III
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- Record sourced from PubMed, PMID 1616337.
- Also identified by PMC identifier 1005705.
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Abstract
Serum samples from 108 unselected Jamaican patients with homozygous sickle cell disease and 116 control subjects with normal haemoglobin were screened for the presence of antiphospholipid antibodies. Slightly increased levels of IgG antiphospholipid antibodies were found in nine patients with sickle cell disease and in none of the control subjects. Serial control samples confirmed the increased levels of antiphospholipid antibodies. A comparison of the haematological and clinical features of patients with positive and negative antiphospholipid sickle cell disease did not highlight any differences between the groups.
Medical subject headings
- Anemia, Sickle Cell
- Antibodies
- Homozygote
- Phospholipids