The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis.
review · Level V
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Abstract
Recent research has highlighted the fundamental role of the tumour's extracellular metabolic microenvironment in malignant invasion. This microenvironment is acidified primarily by the tumour-cell Na(+)/H(+) exchanger NHE1 and the H(+)/lactate cotransporter, which are activated in cancer cells. NHE1 also regulates formation of invadopodia - cell structures that mediate tumour cell migration and invasion. How do these alterations of the metabolic microenvironment and cell invasiveness contribute to tumour formation and progression?
Medical subject headings
- Cation Transport Proteins
- Membrane Proteins
- Neoplasm Metastasis
- Neoplasms
- Sodium-Hydrogen Exchangers