Linkage disequilibrium mapping of quantitative-trait Loci by selective genotyping.
basic_science · Level V
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- Record sourced from PubMed, PMID 16175512.
- Also identified by PMC identifier 1275615.
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Abstract
The principles of linkage disequilibrium mapping of dichotomous diseases can be well applied to the mapping of quantitative-trait loci through the method of selective genotyping. In 1999, M. Slatkin considered a truncation selection (TS) approach. We propose in this report an extended TS approach and an extreme-rank-selection (ERS) approach. The properties of these selection approaches are studied analytically. By using a simulation study, we demonstrate that both the extended TS approach and the ERS approach provide remarkable improvements over Slatkin's original TS approach.
Medical subject headings
- Linkage Disequilibrium
- Quantitative Trait Loci