The survival kinases Akt and Pim as potential pharmacological targets.
review · Level V
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- Record sourced from PubMed, PMID 16200194.
- Also identified by PMC identifier 1236693.
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Abstract
The Akt and Pim kinases are cytoplasmic serine/threonine kinases that control programmed cell death by phosphorylating substrates that regulate both apoptosis and cellular metabolism. The PI3K-dependent activation of the Akt kinases and the JAK/STAT-dependent induction of the Pim kinases are examples of partially overlapping survival kinase pathways. Pharmacological manipulation of such kinases could have a major impact on the treatment of a wide variety of human diseases including cancer, inflammatory disorders, and ischemic diseases.
Medical subject headings
- Apoptosis
- Ischemia
- Neoplasms
- Protein Kinase Inhibitors
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins c-pim-1
- Signal Transduction