Pharmacological manipulation of Bcl-2 family members to control cell death.
basic_science · Level V
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- Record sourced from PubMed, PMID 16200198.
- Also identified by PMC identifier 1236690.
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Abstract
The commitment to programmed cell death involves complex interactions among pro- and antiapoptotic members of the Bcl-2 family of proteins. The physiological result of a decision by these proteins to undergo cell death is permeabilization of the mitochondrial outer membrane. Pharmacologic manipulation of proteins in this family appears both feasible and efficacious, whether the goal is decreased cell death, as in ischemia of the myocardium or brain, or increased cell death, as in cancer.
Medical subject headings
- Brain Ischemia
- Mitochondria
- Myocardial Ischemia
- Neoplasms
- Proto-Oncogene Proteins c-bcl-2