Sweat testing infants detected by cystic fibrosis newborn screening.
cross_sectional · Level IV
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Abstract
Describe and define limitations of early pilocarpine iontophoresis (sweat testing) for cystic fibrosis (CF) newborn screening (NBS). Population-based results from follow-up of CF NBS-positive newborns. Insufficient quantity of sweat is more likely if the sweat test is done too early, but testing is generally successful after 2 weeks of age. Sweat chloride levels drop over the first weeks of life. CF carriers have higher sweat chloride concentrations than non-carriers. Sweat testing can be performed effectively after 2 weeks of age for CF NBS-positive newborns. Earlier testing has a higher risk of insufficient sweat for completing testing.
Medical subject headings
- Chlorides
- Cystic Fibrosis
- Iontophoresis
- Neonatal Screening
- Sweat