The transcription factor Pokemon: a new key player in cancer pathogenesis.
basic_science · Level V
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- Record sourced from PubMed, PMID 16204018.
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Abstract
Learning how critical cell regulatory pathways are controlled may lead to new opportunities for cancer treatment. We recently identified the transcription factor Pokemon as a central regulator of the important tumor suppressor ARF. Pokemon is overexpressed in multiple human cancers and cells lacking Pokemon are refractory to oncogenic transformation. These findings suggest that Pokemon may offer an effective new target for cancer therapeutics.
Medical subject headings
- Cell Transformation, Neoplastic
- DNA-Binding Proteins
- Transcription Factors