The blood-brain barrier--lessons from moody flies.
basic_science · Level V
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- Record sourced from PubMed, PMID 16213208.
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Abstract
Despite the importance of the blood-brain barrier (BBB), little is known about the molecular mechanisms that control its integrity. The identification of moody, a gene required for the formation and maintenance of the Drosophila BBB, provides new insight into how paracellular junctions are formed at the barrier. Meanwhile, moody also has been identified in a screen for fly mutants with altered sensitivity to cocaine, remarkably implicating the BBB in the physiological response to narcotics.
Medical subject headings
- Blood-Brain Barrier
- Drosophila Proteins
- Endothelial Cells
- Receptors, G-Protein-Coupled