Right place, right time, and only once: replication initiation in metazoans.
review · Level V
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- Record sourced from PubMed, PMID 16213209.
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Abstract
DNA replication is tightly regulated at the initiation step by both the cell cycle machinery and checkpoint pathways. Here, we discuss recent advances in understanding how replication is initiated in metazoans at the correct chromosome positions, at the appropriate time, and only once per cell cycle.
Medical subject headings
- DNA Replication
- Mitosis
- Replication Origin