Making ATP.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 16217018.
- Also identified by PMC identifier 1283826.
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Abstract
We present a mesoscopic model for ATP synthesis by F(1)F(o) ATPase. The model combines the existing experimental knowledge of the F(1) enzyme into a consistent mathematical model that illuminates how the stages in synthesis are related to the protein structure. For example, the model illuminates how specific interactions between the gamma, epsilon, and alpha(3)beta(3) subunits couple the F(o) motor to events at the catalytic sites. The model also elucidates the origin of ADP inhibition of F(1) in its hydrolysis mode. The methodology we develop for constructing the structure-based model should prove useful in modeling other protein motors.
Medical subject headings
- Adenosine Triphosphate
- Proton-Translocating ATPases