Three-dimensional preoperative maps of hippocampal atrophy predict surgical outcomes in temporal lobe epilepsy.
retrospective_cohort · Level III
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- Record sourced from PubMed, PMID 16217065.
- Also identified by PMC identifier 2770433.
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Abstract
The authors used surface-based anatomic mapping to detect features of hippocampal anatomy that correlated with surgical outcomes in patients undergoing surgery for mesial temporal lobe epilepsy with hippocampal sclerosis. Compared with a seizure-free group, hippocampal profiles for the non-seizure-free group had greater diffuse ipsilateral atrophy and more region-specific contralateral atrophy in the anterior, lateral hippocampus. These atrophic regions may indicate areas of increased epileptogenicity, contributing to poorer surgical outcomes.
Medical subject headings
- Atrophy
- Brain Mapping
- Epilepsy, Temporal Lobe
- Hippocampus
- Magnetic Resonance Imaging
- Preoperative Care