Clomipramine-induced hypersensitivity syndrome with unusual clinical features.
case_report · Level V
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Abstract
Drug-induced hypersensitivity syndrome is a severe drug eruption with fatal visceral organ failures associated with human herpesvirus-6 (HHV-6) reactivation. We present a case of clomipramine-induced hypersensitivity syndrome, which displayed in succession two different reactions akin to those described for Gianotti-Crosti syndrome and infectious mononucleosis. HHV-6 reactivation was confirmed serologically after the latter reaction, suggesting that our case may have represented a biphasic reaction to HHV-6 reactivation.
Medical subject headings
- Antidepressive Agents, Tricyclic
- Clomipramine
- Drug Hypersensitivity